The Pathologist: Virtual Staining in the Tumor Microenvironment

AI models are generating virtual biomarker staining from hematoxylin and eosin slides at a fraction of the cost and time of the manual technique

Multiplex immunofluorescence (IF) can provide rich spatial and phenotypic information for characterizing the tumor microenvironment – but it comes with practical limitations. Dependent on specialized instrumentation and expertise, the technique is too costly and labor-intensive for many labs. Downstream image analysis often requires substantial computational pathology support, and the technique can be affected by technical variability between runs. Together, these factors can limit scalability and broader adoption.

To counter these barriers, computer models are being developed to generate biomarker staining virtually. The Pathologist connected with Christopher Jackson, Chief Scientific Officer at ViewsML, to learn about our system, presented at USCAP 2026. Read the interview here.

Source: The Pathologist